| Rt Hon Justine Greening | 14 July 2016 | 8 January 2018 |
| Amber Augusta Rudd | 8 January 2018 | 29 April 2018 |
| Susan Frances Maria Williams, Baroness Williams of Trafford | 9 January 2018 | 14 February 2020 |
| Rt Hon Penelope Mary Mordaunt | 30 April 2018 | 24 July 2019 |
| Amber Augusta Rudd | 24 July 2019 | 7 September 2019 |
| Rt Hon Mary Elizabeth Truss | 10 September 2019 | 6 September 2022 |
| Olukemi Olufunto Badenoch | 14 February 2020 | 6 July 2022 |
| Rt Hon Olukemi Olufunto Badenoch | 25 October 2022 | 5 July 2024 |
| Dr Anneliese Jane Dodds | 8 July 2024 | 28 February 2025 |