| Rt Hon Arthur Neville Chamberlain | 6 November 1924 | 4 June 1929 |
| Rt Hon Robert Hugh Turton | 1955 | 1957 |
| Bernard Richard Braine | July 1962 | October 1964 |
| Rt Hon Kenneth Harry Clarke | 25 July 1988 | 1 November 1990 |
| Hon William Arthur Waldegrave | 1990 | 11 April 1992 |
| Rt Hon Virginia Hilda Brunette Maxwell Bottomley | 11 April 1992 | 5 July 1995 |
| Rt Hon Stephen James Dorrell | 5 July 1995 | 2 May 1997 |
| Rt Hon Frank Gordon Dobson | 3 May 1997 | 11 October 1999 |
| Rt Hon Alan Milburn | 11 October 1999 | 12 June 2003 |
| Rt Hon Dr John Reid | 12 June 2003 | 6 May 2005 |
| Rt Hon Patricia Hope Hewitt | 6 May 2005 | 27 June 2007 |
| Rt Hon Alan Arthur Johnson | 28 June 2007 | 5 June 2009 |
| Rt Hon Andrew Murray Burnham | 5 June 2009 | 11 May 2010 |
| Andrew David Lansley | 11 May 2010 | 4 September 2012 |
| Rt Hon Jeremy Richard Streynsham Hunt | 4 September 2012 | 7 January 2018 |