| Rt Hon Jeremy Richard Streynsham Hunt | 7 January 2018 | 9 July 2018 |
| Rt Hon Matthew John David Hancock | 9 July 2018 | 26 June 2021 |
| Rt Hon Sajid Javid | 26 June 2021 | 5 July 2022 |
| Stephen Paul Barclay | 5 July 2022 | 6 September 2022 |
| Dr Th?r?se Anne Coffey | 6 September 2022 | 25 October 2022 |
| Stephen Paul Barclay | 25 October 2022 | 13 November 2023 |
| Victoria Mary Atkins | 13 November 2023 | 5 July 2024 |
| Wesley Paul William Streeting | 5 July 2024 |